PP2

Src kinase inhibitor

Catalog No. SIH-470

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CAS No. 172889-27-9
Molecular Formula C15H16ClN5
SKU: SIH-470 Categories: ,

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SIH-470_PP2_Chemical_Structure.png
Product Name PP2
Description

Src kinase inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 172889-27-9
Molecular Formula C15H16ClN5
Molecular Weight 301.8
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (25mg/mL); or ethanol (3mg/mL, warm)
Source Synthetic
Appearance Off-white solid
SMILES C1=C(C=CC(=C1)Cl)C2=N[N](C3=C2C(=NC=N3)N)C(C)(C)C
InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChIKey PBBRWFOVCUAONR-UHFFFAOYSA-N
Safety Phrases Classification:
Acute Toxicity: Oral, Category 3

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H301: Toxic if swallowed.

Precautionary statements:
P264: Wash {hands} thoroughly after handling.
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330: Rinse mouth
Cite This Product PP2 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-470)

Biological Description

Alternative Names 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 4878
Scientific Background PP2 is a selective inhibitor of Src-family tyrosine kinases. PP2 has been shown to inhibit Lck, FynT, and phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). PP2 displays > 10000-fold selectivity over ZAP-70 and JAK2.
References 1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701.
2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.

Product Images

<p>Chemical structure of PP2 (SIH-470), a Src family kinase inhibitor. CAS #: 172889-27-9. Molecular Formula: C15H16ClN5. Molecular Weight: 301.8 g/mol.</p>

Chemical structure of PP2 (SIH-470), a Src family kinase inhibitor. CAS #: 172889-27-9. Molecular Formula: C15H16ClN5. Molecular Weight: 301.8 g/mol.

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