PP2

Name: PP2
SKU: SIH-470
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Src kinase inhibitor

Catalog No. SIH-470

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CAS No.	172889-27-9
Molecular Formula	C15H16ClN5

SKU: SIH-470 Categories: Inhibitor, Small Molecules

Product Name	PP2
Description	Src kinase inhibitor
Purity	>98% (TLC); NMR (Conforms)
CAS No.	172889-27-9
Molecular Formula	C₁₅H₁₆ClN₅
Molecular Weight	301.8
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	May be dissolved in DMSO (25mg/mL); or ethanol (3mg/mL, warm)
Source	Synthetic
Appearance	Off-white solid
SMILES	C1=C(C=CC(=C1)Cl)C2=N[N](C3=C2C(=NC=N3)N)C(C)(C)C
InChI	InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChIKey	PBBRWFOVCUAONR-UHFFFAOYSA-N
Safety Phrases	Classification: Acute Toxicity: Oral, Category 3 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301: Toxic if swallowed. Precautionary statements: P264: Wash {hands} thoroughly after handling. P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P330: Rinse mouth
Cite This Product	PP2 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-470)

Alternative Names	3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	4878
Scientific Background	PP2 is a selective inhibitor of Src-family tyrosine kinases. PP2 has been shown to inhibit Lck, FynT, and phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). PP2 displays > 10000-fold selectivity over ZAP-70 and JAK2.
References	1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701. 2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.

Chemical structure of PP2 (SIH-470), a Src family kinase inhibitor. CAS #: 172889-27-9. Molecular Formula: C15H16ClN5. Molecular Weight: 301.8 g/mol.

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