Pridopidine

Name: Pridopidine
SKU: SIH-626
Availability: InStock

Neuroprotective

Catalog No. SIH-626

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CAS No.	346688-38-8
Molecular Formula	C15H23NO2S

SKU: SIH-626 Categories: Inhibitor, Small Molecules

Product Name	Pridopidine
Description	Neuroprotective
Purity	>98% (TLC); NMR (Conforms)
CAS No.	346688-38-8
Molecular Formula	C₁₅H₂₃NO₂S
Molecular Weight	281.4
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	May be dissolved in DMSO (10 mg/ml)
Source	Synthetic
Appearance	White powder
SMILES	CCCN1CCC(C2=CC(S(C)(=O)=O)=CC=C2)CC1
InChI	1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3
InChIKey	YGKUEOZJFIXDGI-UHFFFAOYSA-N
Safety Phrases	Classification: Warning GHS Hazard Statements,: H302, H361d Precautionary Statement Codes,: P203, P264, P270, P280, P301+P317, P318, P330, P405, and P501
Cite This Product	Pridopidine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-626)

Alternative Names	4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine; ACR16
Research Areas	ALS Disease, Neurodegeneration, Neuroscience
PubChem ID	9795739
Scientific Background	Potential treatment for Huntington’s disease, Parkinson’s disease, and schizophrenia (1,2). Able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics (“dopamine stabilizer”) (3). More recent studies have attributed pridopidine’s effects to its being a more potent sigma-1 ligand than a D2 ligand (4,5). Displays neuroprotective/restorative effects (6,7) and ameliorates central features of amyotrophic lateral sclerosis pathology (8) in a sigma-1-mediated manner.
References	1. F Pettersson et al. 2010 J. Med. Chem. 53:2510. 2. S Natesan et al. 2006 J. Pharmacol. Exp. Ther. 318:810. 3. T Dyhring et al. 2010 Eur. J. Pharmacol. 628:19. 4. K Sahlholm et al. 2015 Psychopharmacology (Berl) 232:3443. 5. K Sahlholm et al. 2013 Mol. Psychiatry 18:12. 6. V Francardo et al. 2019 Neurotherapeutics 16:465. 7. D Ryskamp et al. 2017 Neurobiol. Dis. 7 97(Pt A):46. 8. A Ionescu et al. 2019 Cell Death Dis. 10:210.

Chemical structure of Pridopidine (SIH-626), a Neuroprotective. CAS #: 346688-38-8. Molecular Formula: C15H23NO2S. Molecular Weight: 281.4 g/mol.

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