Product Name | Pyr3 |
Description |
TRPC3 Channel blocker |
Purity | >98% |
CAS No. | 1160514-60-2 |
Molecular Formula | C16H11Cl3F3N3O3 |
Molecular Weight | 456.63 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Inhibitor |
Solubility | Soluble to 100 mM in DMSO |
Source | Synthetic |
Appearance | White Solid |
SMILES | CCOC(=O)C1=C(N(N=C1)C2=CC=C(C=C2)NC(=O)C(=C(Cl)Cl)Cl)C(F)(F)F |
InChI | InChI=1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26) |
InChIKey | RZHGONNSASQOAY-UHFFFAOYSA-N |
Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
Cite This Product | Pyr3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-306) |
Alternative Names | Ethyl 1-{4-[(2,3,3-trichloroacryloyl)amino]phenyl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate |
Research Areas | Ion Channels, Neuroscience |
PubChem ID | 56964346 |
Scientific Background | Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor of activated T cells and hypertrophic growth in myocytes and pressure overloaded-induced hypertrophy in vivo (1). |
References | 1. Kiyonaka S., Kato K., Nishida M., and Mori Y. (2010) Yakugaku Zasshi. 130(3): 303-311. |
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