Pyr3

TRPC3 Channel blocker

Catalog No. SIH-306

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CAS No. 1160514-60-2
Molecular Formula C16H11Cl3F3N3O3
SKU: SIH-306 Categories: ,

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SIH-306_Pyr3_Chemical_Structure.png
Product Name Pyr3
Description

TRPC3 Channel blocker

Purity >98%
CAS No. 1160514-60-2
Molecular Formula C16H11Cl3F3N3O3
Molecular Weight 456.63
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance White Solid
SMILES CCOC(=O)C1=C(N(N=C1)C2=CC=C(C=C2)NC(=O)C(=C(Cl)Cl)Cl)C(F)(F)F
InChI InChI=1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
InChIKey RZHGONNSASQOAY-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Pyr3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-306)

Biological Description

Alternative Names Ethyl 1-{4-[(2,3,3-trichloroacryloyl)amino]phenyl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
Research Areas Ion Channels, Neuroscience
PubChem ID 56964346
Scientific Background Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor of activated T cells and hypertrophic growth in myocytes and pressure overloaded-induced hypertrophy in vivo (1).
References 1. Kiyonaka S., Kato K., Nishida M., and Mori Y. (2010) Yakugaku Zasshi. 130(3): 303-311.

Product Images

<p>Chemical structure of Pyr3 (SIH-306), a TRPC3 Channel blocker. CAS #: 1160514-60-2. Molecular Formula: C16H11Cl3F3N3O3. Molecular Weight: 456.63 g/mol.</p>

Chemical structure of Pyr3 (SIH-306), a TRPC3 Channel blocker. CAS #: 1160514-60-2. Molecular Formula: C16H11Cl3F3N3O3. Molecular Weight: 456.63 g/mol.

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