Roscovitine

p34/cdc2 inhibitor

Catalog No. SIH-472

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CAS No. 186692-46-6
Molecular Formula C19H26N6O
SKU: SIH-472 Categories: ,

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SIH-472_Roscovitine_Chemical_Structure.png
Product Name Roscovitine
Description

p34/cdc2 inhibitor

Purity >99% (TLC and HPLC); NMR (Conforms)
CAS No. 186692-46-6
Molecular Formula C19H26N6O
Molecular Weight 354.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in ethanol (10mg/mL); or DMSO (10mg/mL, warm)
Source Synthetic
Appearance White to off-white solid
SMILES [C@H](NC2=NC1=C(N=C[N]1C(C)C)C(=N2)NCC3=CC=CC=C3)(CO)CC
InChI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChIKey BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Roscovitine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-472)

Biological Description

Alternative Names 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine, 2(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
Research Areas Cell Signaling
PubChem ID 160355
Scientific Background Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). It is specifically selective for CDK1/cyclin B kinase, CDK2 and CDK5/p35. It inhibits M phase promoting factor kinase activity and affects calcium channel gating.
References 1. De Azevedo, et al. (1997) Eur. J. Biochem. 243(1-2): 518–526.

Product Images

<p>Chemical structure of Roscovitine (SIH-472), a p34/cdc2 inhibitor. CAS #: 186692-46-6. Molecular Formula: C19H26N6O. Molecular Weight: 354.4 g/mol.</p>

Chemical structure of Roscovitine (SIH-472), a p34/cdc2 inhibitor. CAS #: 186692-46-6. Molecular Formula: C19H26N6O. Molecular Weight: 354.4 g/mol.

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