Safinamide

Name: Safinamide
SKU: SIH-625
Availability: InStock

MAO-B Inhibitor

Catalog No. SIH-625

0 out of 5 based on 0 customer ratings

Reviews (0) | Datasheet

CAS No.	133865-89-1
Molecular Formula	C17H19FN2O2

SKU: SIH-625 Categories: Inhibitor, Small Molecules

Product Name	Safinamide
Description	MAO-B Inhibitor
Purity	>98% (HPLC); NMR (conforms)
CAS No.	133865-89-1
Molecular Formula	C₁₇H₁₉FN₂O₂
Molecular Weight	302.3
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	May be dissolved in DMSO (50 mg/ml)
Source	Synthetic
Appearance	White powder
SMILES	CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F
InChI	InChI=1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1
InChIKey	NEMGRZFTLSKBAP-LBPRGKRZSA-N
Safety Phrases	Classification: Danger GHS Hazard Statements,: H301 H318 H400 Precautionary Statement Codes, P264, P264+P265, P270, P273, P280, P301+P316, P305+P354+P338, P317, P321, P330, P391, P405, and P501
Cite This Product	Safinamide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-625)

Alternative Names	(S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; FCE-26743; PNU-151774E; NW-1015
Research Areas	Neurodegeneration, Neuroscience, Parkinson's Disease
PubChem ID	131682
Scientific Background	A selective and reversible inhibitor of monoamine oxidase B (MAO-B, IC50=98 nM with greater than 100-fold selectivity over MAO-A) (1). It displays anticonvulsant activity (2) and protects against kainate-induced seizures and hippocampal neurodegeneration in rat models (3). Reduces overactive glutamatergic signaling via use-dependent sodium channel blockade (4). A novel therapeutic for Parkinson’s disease with multiple modes of action (5). Effective as an add-on to dopamine agonist therapy in early Parkinson’s Disease(6).
References	1. MS Strolin Benedetti et al. 1994 J. Pharm. Pharmacol. 46:814 2. RG Fariello et al. 1998 J. Pharmacol. Exp. Ther. 285:397 3. R Maj et al.1998 Eur. J. Pharmacol. 8 359:27 4. F Gardoni et al. 2018 J. Pharmacol. Exp. Ther. 2018 367:442 5. C Caccia et al. 2006 Neurology 67(7 Suppl. 2):S18 6. AH Schapira et al. 2013 Eur. J. Neurol. 20:271

Chemical structure of Safinamide (SIH-625), a MAO-B Inhibitor. CAS #: 133865-89-1. Molecular Formula: C17H19FN2O2 . Molecular Weight: 302.3 g/mol.

There are no reviews yet.

Be the first to review “Safinamide”