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| Product Name | SAHA (Vorinostat) |
| Description |
HDAC inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 149647-78-9 |
| Molecular Formula | C14H20N2O3 |
| Molecular Weight | 264.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO |
| InChI | InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) |
| InChIKey | WAEXFXRVDQXREF-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H341-H360 (Suspected of causing genetic defects) Precautionary Statements: P201-P281-P308 + P313 |
| Cite This Product | SAHA (Vorinostat) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-359) |
Biological Description
| Alternative Names | Suberoylanilide-hydroxamic acid; Vorinostat; N-Hydroxy-N'-phenyloctanediamide |
| Research Areas | Cancer, Cell Signaling |
| PubChem ID | 5311 |
| Scientific Background | Potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. Synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable. |
| References |
1. Vrana J.A., et al., (1999) Oncogene. 18: 7016. 2. Butler L.M., et al., (2002) Proc. Natl. Acad. Sci. USA. 99: 11700. 3. Tang Y., et al., (2012) Cancer Biol. Ther. 2012 13(7): 567-574. |
Product Images
Chemical structure of SAHA (Vorinostat) (SIH-359), a HDAC inhibitor. CAS #: 149647-78-9. Molecular Formula: C14H20N2O3. Molecular Weight: 264.3 g/mol.
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