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| Product Name | Santacruzamate A |
| Description |
Ultrapotent HDAC2 inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 1477949-42-0 |
| Molecular Formula | C15H22N2O3 |
| Molecular Weight | 278.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (25 mg/ml); or Ethanol (20 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C1, O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C2, O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C3 |
| InChI | InChI=1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19) |
| InChIKey | HTOYBIILVCHURC-UHFFFAOYSA-N |
| Safety Phrases | GHS Hazard Statements: Not Classified |
| Cite This Product | Santacruzamate A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-613) |
Biological Description
| Alternative Names | N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester |
| Research Areas | Alzheimer's Disease, Apoptosis, Cancer, Neurodegeneration, Neuroscience |
| PubChem ID | 72946782 |
| Scientific Background | Santacruzamate A is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively) (1). It induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors (2). It has been been investigated as a potential therapeutic agent for breast cancer (3). Attenuates A fragment (A25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance4. Ameliorates Alzheimer’s disease-like pathology in mouse models (4). |
| References |
1. Pavlik C.M., et al. (2013) J. Nat. Prod. 76:2026 2.Zhou et al. H., (2018) Cell Prolif. 51(3):e12477 3. Damaskos C., et al. (2017) Anticancer Res. 37:35 4.Chen L., et al. (2019) Front. Cell. Neurosci. 13:61 |
Product Images
Chemical structure of Santacruzamate A (SIH-613), a Ultrapotent HDAC2 inhibitor. CAS #: 1477949-42-0. Molecular Formula: C15H22N2O3. Molecular Weight: 278.4 g/mol.
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