SKF-96365

TRPC channel blocker

Catalog No. SIH-305

0 out of 5 based on 0 customer ratings
CAS No. 130495-35-1
Molecular Formula C22H26N2O3.HCl
SKU: SIH-305 Categories: ,

Clear
SIH-305_SKF-96365_Chemical_Structure.png
Product Name SKF-96365
Description

TRPC channel blocker

Purity >98%
CAS No. 130495-35-1
Molecular Formula C22H26N2O3.HCl
Molecular Weight 402.92
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in water
Source Synthetic
Appearance White solid
SMILES COC1=CC=C(C=C1)CCCOC(CN2C=CN=C2)C3=CC=C(C=C3)OC.Cl
InChI InChI=1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4
InChIKey FWLPKVQUECFKSW-UHFFFAOYSA-N
Safety Phrases Classification: Irritant. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
Cite This Product SKF-96365 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-305)

Biological Description

Alternative Names 1-{2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl}-1H-imidazole hydrochloride (1:1)
Research Areas Ion Channels, Neuroscience
PubChem ID 104956
Scientific Background SKF-96365 is a selective inhibitor of receptor mediated Ca2+ entry and voltage-gated Ca2+ entry (1). It has also been shown o inhibit cytochrome P-450 mediated reactions (1,2), and reversibly activates non-selective cation channels in human endotherlial cells (1,3).
References 1. Leis H.J., et al. (1995) Br J Pharmacol. 114(3): 598-601.
2. Sheets J.J., Mason J.I., Wise C.A. and Eastabrook R.W. (1986) Biochem Pharmacol. 35: 487-491.
3. Schwarz G., Droogmans G. and Nilius B. (1994) Cell Calcium. 15: 45-54.

Product Images

<p>Chemical structure of SKF-96365 (SIH-305), a TRPC channel blocker. CAS #: 130495-35-1. Molecular Formula: C22H26N2O3.HCl. Molecular Weight: 402.92 g/mol.</p>

Chemical structure of SKF-96365 (SIH-305), a TRPC channel blocker. CAS #: 130495-35-1. Molecular Formula: C22H26N2O3.HCl. Molecular Weight: 402.92 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “SKF-96365”

Your email address will not be published. Required fields are marked *