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| Product Name | SP600125 |
| Description |
Jnk inhibitor |
| Purity | >98% |
| CAS No. | 129-56-6 |
| Molecular Formula | C14H8N2O |
| Molecular Weight | 220.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO or methanol |
| Source | Synthetic |
| Appearance | Yellow to brown solid |
| SMILES | C1=CC=C4C3=C1C(=O)C2=CC=CC=C2C3=N[NH]4 |
| InChI | InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) |
| InChIKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
| Safety Phrases |
Classification: D2B - Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H315 - Causes skin irritation. H319 - Causes serious eye irritation. H335 - May cause respiratory irritation Precautionary Phrases: P261 - Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 - Wash skin thoroughly after handling. P271 - Use only outdoors or in a well-ventilated area. P280 - Wear protective gloves/ eye protection/ face protection. P302 + P352 - IF ON SKIN: Wash with plenty of soap and water. P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 – Call a POISON CENTER or doctor/ physician if you feel unwell. P321 - Specific treatment (see supplemental first aid instructions on this label). P332 + P313 - If skin irritation occurs: Get medical advice/ attention. P337 + P313 - If eye irritation persists: Get medical advice/ attention. P362 - Take off contaminated clothing and wash before reuse. P403 + P233 - Store in a well - ventilated place. Keep container tightly closed. P405 - Store locked up. P501 - Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | SP600125 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-381) |
Biological Description
| Alternative Names | Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone |
| Research Areas | Apoptosis, Cancer, Cell Signaling |
| PubChem ID | 8515 |
| Scientific Background | Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 µM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. |
| References |
1. Bennett B.L., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(24): 13681-6. 2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63. 3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204. 4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75. |
Product Images
Chemical structure of SP600125 (SIH-381), a Jnk inhibitor. CAS #: 129-56-6. Molecular Formula: C14H8N2O. Molecular Weight: 220.2 g/mol.
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Based on validation through cited publications.