Spautin-1

Autophagy inhibitor

Catalog No. SIH-404

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CAS No. 1262888-28-7
Molecular Formula C15H11F2N3
SKU: SIH-404 Categories: ,

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SIH-404_Spautin-1_Chemical_Structure.png
Product Name Spautin-1
Description

Autophagy inhibitor

Purity ≥98% (TLC); NMR (Conforms)
CAS No. 1262888-28-7
Molecular Formula C15H11F2N3
Molecular Weight 271.26
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (50mg/mL); or ethanol (15mg/mL, warm)
Source Synthetic
Appearance White to beige powder.
SMILES c1cc(ccc1CNc2c3cc(ccc3ncn2)F)F
InChI InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChIKey AWIVHRPYFSSVOG-UHFFFAOYSA-N
Safety Phrases Classification: D2B- Toxic Material Causing Other Toxic Effects, Severe eye irritant
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H318- Causes serious eye damage.
Precautionary statements:
P280- Wear protective gloves/ eye protection/ face protection.
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product Spautin-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-404)

Biological Description

Alternative Names 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
Research Areas Autophagy, Cancer
PubChem ID 51037431
Scientific Background Spautin-1 inhibits the deubiquitination activity of USP10 and USP13, two ubiquitin-specific peptidases. This results in the degradation of class III PI3 kinase complexes. Because this group of kinases regulates autophagy, Spautin-1 in turn inhibits autophagy.
References 1. Liu J., et al. (2011) Cell. 147(1): 223-34.

Product Images

<p>Chemical structure of Spautin-1 (SIH-404), a Autophagy inhibitor. CAS #: 1262888-28-7. Molecular Formula: C15H11F2N3. Molecular Weight: 271.26 g/mol.</p>

Chemical structure of Spautin-1 (SIH-404), a Autophagy inhibitor. CAS #: 1262888-28-7. Molecular Formula: C15H11F2N3. Molecular Weight: 271.26 g/mol.

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