STO 609

Name: STO 609
SKU: SIH-479
Availability: InStock

CAMKK kinase inhibitor

Catalog No. SIH-479

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CAS No.	52029-86-4
Molecular Formula	C21H14N2O5

SKU: SIH-479 Categories: Inhibitor, Small Molecules

Product Name	STO 609
Description	CAMKK kinase inhibitor
Purity	>98% (TLC)
CAS No.	52029-86-4
Molecular Formula	C₂₁H₁₄N₂O₅
Molecular Weight	374.3
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (10 mg/ml)
Source	Synthetic
Appearance	Yellow solid
SMILES	CC(=O)O.C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=CC5=C(C=CC3=C54)C(=O)O
InChI	InChI=1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)
InChIKey	WNRSTFUVBWNELX-UHFFFAOYSA-N
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product	STO 609 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-479)

Alternative Names	7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	16760660
Scientific Background	STO 609 is a potent, competitive and selective inhibitor of Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK). STO 609 has been shown to bind to the CaMKK catalytic domain, consequently inhibiting autophosphorylation. It is a valuable tool for exploring the role of the CaM-KK pathway in various physiological processes. STO 609 is cell-permeable.
References	1. Tokumitsu, H., et al. (2002) J. Biol. Chem. 277(18): 15813–15818. 2. Levine Y.C., Li G.K., & Michel T. (2007) J. Biol. Chem. 282(28): 20351–20364. 3. Anderson K.A., et al. (2008) Cell Metabolism. 7(5): 377–388.

Chemical structure of STO 609 (SIH-479), a CAMKK kinase inhibitor. CAS #: 52029-86-4. Molecular Formula: C21H14N2O5. Molecular Weight: 374.3 g/mol.

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