SU 4312

VEGFR, PDGFR kinase inhibitor

Catalog No. SIH-481

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CAS No. 07-07-12
Molecular Formula C17H16N2O
SKU: SIH-481 Categories: ,

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SIH-481_SU-4312_Chemical_Structure.png
Product Name SU 4312
Description

VEGFR, PDGFR kinase inhibitor

Purity >98% (HPLC)
CAS No. 07-07-12
Molecular Formula C17H16N2O
Molecular Weight 264.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (25 mg/ml)
Source Synthetic
Appearance Orange solid
SMILES C1=CC=CC3=C1C(=C/C2=CC=C(N(C)C)C=C2)/C(=O)N3
InChI InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11-
InChIKey UAKWLVYMKBWHMX-PTNGSMBKSA-N
Safety Phrases Classification:
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product SU 4312 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-481)

Biological Description

Alternative Names 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 6450842
Scientific Background SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases, including VEGFR-2 (Flk-1, KDR).
References 1. Zaman G.J., et al. (1999) Biochem. Pharm. 57(1): 57–64.
2. Shimotake J., Derugin N., Wendland M., Vexler Z.S., & Ferriero D.M. (2010) Stroke. 41(2): 343–349.
3. Schultheiss C., et al. (2006) Angiogenesis. 9(2): 59–65.

Product Images

<p>Chemical structure of SU 4312 (SIH-481), a VEGFR / PDGFR kinase inhibitor. CAS #: 5812-07-7. Molecular Formula: C17H16N2O. Molecular Weight: 264.3 g/mol.</p>

Chemical structure of SU 4312 (SIH-481), a VEGFR / PDGFR kinase inhibitor. CAS #: 5812-07-7. Molecular Formula: C17H16N2O. Molecular Weight: 264.3 g/mol.

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