SU1498

VEGFR kinase inhibitor

Catalog No. SIH-480

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CAS No. 168835-82-3
Molecular Formula C25H30N2O2
SKU: SIH-480 Categories: ,

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SIH-480_SU-1498_Chemical_Structure.png
Product Name SU1498
Description

VEGFR kinase inhibitor

Purity >98%
CAS No. 168835-82-3
Molecular Formula C25H30N2O2
Molecular Weight 390.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO
Source Synthetic
Appearance Solid
SMILES CC(C)C1=CC(=CC(=C1O)C(C)C)/C=C(C#N)/C(=O)NCCCC2=CC=CC=C2
InChI InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
InChIKey JANPYFTYAGTSIN-FYJGNVAPSA-N
Safety Phrases Classification:
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product SU1498 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-480)

Biological Description

Alternative Names (E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide, Tyrphostin SU 1498
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 5941539
Scientific Background SU1498 is a potent and selective inhibitor of Flk-1, a VEGF receptor kinase, and VEGFR2.
References 1. Kisielewska J., Ligeza J., & Klein A. (2008) Folia Histochemica Et Cytobiologica. 46(2): 185–191.
2. Cebulla C.M., et al. (2008) Ophthal J. 2: 62–67.

Product Images

<p>Chemical structure of SU1498 (SIH-480), a VEGFR kinase inhibitor. CAS #: 168835-82-3. Molecular Formula: C25H30N2O2. Molecular Weight: 390.5 g/mol.</p>

Chemical structure of SU1498 (SIH-480), a VEGFR kinase inhibitor. CAS #: 168835-82-3. Molecular Formula: C25H30N2O2. Molecular Weight: 390.5 g/mol.

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