Discovery through Partnership | Excellence through Quality
| Product Name | Temozolomide |
| Description |
AGT inhibitor |
| Purity | >99% (TLC); NMR(Conforms) |
| CAS No. | 85622-93-1 |
| Molecular Formula | C6H6N6O2 |
| Molecular Weight | 194.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (25 mg/ml, warm) or water (weakly) |
| Source | Synthetic |
| Appearance | Off white powder |
| SMILES | CN1C(=O)N2C=NC(=C2N=N1)C(=O)N |
| InChI | InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13) |
| InChIKey | BPEGJWRSRHCHSN-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Toxic Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H350 May cause cancer. H360 May damage fertility or the unborn child. Precautionary Phrases: P201 Obtain special instructions before use. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice or attention. |
| Cite This Product | Temozolomide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-363) |
Biological Description
| Alternative Names | 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5394 |
| Scientific Background | Temozolomide is a membrane permeable DNA alkylating agent which acts as an anti-tumor and anti-angiogenic agent by alkylating the N-7 or O-6 positions of guanine residues which triggers tumor cell death (1-2). It has been used clinically as an anti-cancer agent (3) and has been found to induce autophagy in a variety of cell lines (4). |
| References |
1. Kurzen H., et al. (2003) Anticancer Drugs. 14: 515. 2. Gunther W., et al. (2003) Br. J. Cancer. 88: 463. 3. Danson S.J., et al. (2001) Expert Rev. Anticancer Ther. 10: 13. 4. Natsumeda M., et al. (2011) Neuropathology. 31: 486. |
Product Images
Chemical structure of Temozolomide (SIH-363), a DNA alkylator / apoptosis inducer. CAS #: 85622-93-1. Molecular Formula: C6H6N6O2. Molecular Weight: 194.2 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.