Tranilast

Angiogenesis inhibitor

Catalog No. SIH-369

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CAS No. 53902-12-8
Molecular Formula C18H17NO5
SKU: SIH-369 Categories: ,

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SIH-369_Tranilast_Chemical_Structure.png
Product Name Tranilast
Description

Angiogenesis inhibitor

Purity >95% (HPLC)
CAS No. 53902-12-8
Molecular Formula C18H17NO5
Molecular Weight 327.33
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO.
Source Synthetic
Appearance Off-white to yellow powder.
SMILES COC1=C(C=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O)OC
InChI InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
InChIKey NZHGWWWHIYHZNX-CSKARUKUSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302 – Harmful if swallowed.
H312 – Harmful in contact with skin.
H332 – Harmful if inhaled.
Precautionary Phrases:
P261 – Avoid breathing dust/fume/gas/mist/vapours/spray
P280 – Wear protective gloves/protective clothing/eye protection/face protection.
P301+ P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304+P340 – IF INHALED: remove victim to fresh air and keep at rest in a position comfortable for breathing.
P501 – Dispose of contents/container in accordance with local/regional/national/ international regulations.
Cite This Product Tranilast (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-369)

Biological Description

Alternative Names 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2- enoyl]amino}benzoic acid
Research Areas Cancer, Cardiovascular System, Cell Signaling, Neuroscience
PubChem ID 5282230
Scientific Background Tranilast is an antiallergic, antifibrotic drug that inhibits collagen synthesis, when administered in a dose –dependent manner for a 48 h treatment (1). As an antifibrotic agent, studies shown an effect on the growth of metastasis of mammary carcinoma. It is associated with the inhibition of the growth factor –beta. (TGF-beta) (2).
References 1. Yamada H., Tajima S., Nishikawa T., Murad S., and Pinnell S., (1999) The Journal of Biochemistrystry. 116(4): 892-897.
2. Chakrabarti R., Subramanian V., Abadalla J., Jothy S., Predhomme GJ. (2009) Anticancer Drugs. 20(5): 334-45.

Product Images

<p>Chemical structure of Tranilast (SIH-369), a Angiogenesis inhibitor. CAS #: 53902-12-8. Molecular Formula: C18H17NO5  . Molecular Weight: 327.33 g/mol.</p>

Chemical structure of Tranilast (SIH-369), a Angiogenesis inhibitor. CAS #: 53902-12-8. Molecular Formula: C18H17NO5 . Molecular Weight: 327.33 g/mol.

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