Vildagliptin

Anti-diabetic agent

Catalog No. SIH-567

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CAS No. 274901-16-5
Molecular Formula C17H25N3O2
SKU: SIH-567 Categories: ,

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SIH-567-Vildagliptin-Chemical-Structure.png
Product Name Vildagliptin
Description

Anti-diabetic agent

Purity >98% (HPLC); NMR (conforms)
CAS No. 274901-16-5
Molecular Formula C17H25N3O2
Molecular Weight 303.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml)
Source Synthetic
Appearance White powder
SMILES C1C[C@@H](C#N)N(C1)C(=O)CN[C@]12C[C@@H]3C[C@H](C1)C[C@@](C3)(C2)O
InChI InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12-,13+,14-,16+,17-/m0/s1
InChIKey SYOKIDBDQMKNDQ-NHMCJKAESA-N
Safety Phrases Signal Word: Warning GHS Classifcation: GHS07 Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3 Hazard statement(s):
H302 H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary statement(s):
P301 + P312 + P330-P305 + P351 + P338
Cite This Product Vildagliptin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-567)

Biological Description

Alternative Names (S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile; LAF237
Research Areas Alzheimer's Disease, Atherosclerosis, Cardiovascular System, Diabetes Associated, Neurodegeneration, Neuroscience
PubChem ID 11077541
Scientific Background Vildagliptin is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1) (1). Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia) (2). It is a clinically useful antidiabetic agent.
References 1. B Balas et al., (2007) J. Clin. Endocrinol. Metab. 92:1249.
2. B Ahren et al., (2004) J. Clin. Endocrinol. Metab. 89:2078.

Product Images

<p>Chemical structure of Vildagliptin (SIH-567), a Antidiabetic Agent. CAS #: 274901-16-5 . Molecular Formula: C17H25N3O2. Molecular Weight: 303.4 g/mol.</p>

Chemical structure of Vildagliptin (SIH-567), a Antidiabetic Agent. CAS #: 274901-16-5 . Molecular Formula: C17H25N3O2. Molecular Weight: 303.4 g/mol.

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