VU0467154

M4 Receptor Agonist

Catalog No. SIH-184

5 out of 5 based on 1 customer rating
CAS No. 1451993-15-9
Molecular Formula C17H15F3N4O3S2
SKU: SIH-184 Categories: ,

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SIH-184_VUO467154_Chemical_Structure.png
Product Name VU0467154
Description

M4 Receptor Agonist

Purity >98% (HPLC)
CAS No. 1451993-15-9
Molecular Formula C17H15F3N4O3S2
Molecular Weight 444.45
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Product Type Inhibitor
Solubility Soluble in DMSO
Source Synthetic
Appearance Tan Solid
SMILES O=S(C1=CC=C(C=C1)CNC(C2=C(N)C 3=C(C)C(C)=NN=C3S2)=O)(C(F)(F)F)= O
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product VU0467154 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-184)

Biological Description

Alternative Names 5-amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2,3-c]pyridazine-6-carboxamide
Research Areas Neurodegeneration, Neuroscience, Neurotransmitter Receptors, NMDA Receptors
PubChem ID PMC4324418
Scientific Background Allosteric activators of the M4 muscarinic acetylcholine receptor represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice.
References 1. Bubser M., et. al. (2014) ACS Clinical Neuroscience 5: 920 - 942.

Product Images

<p>Chemical structure of VU0467154 (SIH-184), a M4 Receptor Agonist. CAS #: 1451993-15-9. Molecular Formula: C17H15F3N4O3S2. Molecular Weight: 444.45 g/mol.</p>

Chemical structure of VU0467154 (SIH-184), a M4 Receptor Agonist. CAS #: 1451993-15-9. Molecular Formula: C17H15F3N4O3S2. Molecular Weight: 444.45 g/mol.

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