Discovery through Partnership | Excellence through Quality
| Product Name | WHI P131 |
| Description |
JAK3 kinase inhibitor |
| Purity | >98% |
| CAS No. | 202475-60-3 |
| Molecular Formula | C16H15N3O3 |
| Molecular Weight | 297.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC |
| InChI | InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19) |
| InChIKey | HOZUXBLMYUPGPZ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | WHI P131 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-485) |
Biological Description
| Alternative Names | WHI-P131, Janex 1, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 3794 |
| Scientific Background | WHI P131 also known as Janex-1, is a reversible, potent, and specific inhibitor of JAK3. WHI P131 is cell permeable. It has been seen to inhibit glioblastoma cell adhesion and migration, as well as, thrombin-induced platelet aggregation. |
| References | 1. Sudbeck E.A., et al. (1999) Clin. Cancer Res: J. Am. Asso. Cancer Res. 5(6): 1569–1582. |
Product Images
Chemical structure of WHI P131 (SIH-485), a JAK3 kinase inhibitor. CAS #: 202475-60-3. Molecular Formula: C16H15N3O3. Molecular Weight: 297.3 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.