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| Product Name | 5-Ethynyl-2′-deoxyuridine |
| Description |
DNA labeling agent |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 61135-33-9 |
| Molecular Formula | C11H12N2O5 |
| Molecular Weight | 252.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Labelling Agent |
| Solubility | May be dissolved in DMSO (10 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | O=C(NC(C(C#C)=C1)=O)N1[C@H]2C[C@H](O)[C@@H](CO)O2 |
| InChI | InChI=1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1 |
| InChIKey | CDEURGJCGCHYFH-DJLDLDEBSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | 5-Ethynyl-2'-deoxyuridine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-597) |
Biological Description
| Alternative Names | 2'-Deoxy-5-ethynyluridine; 5-EdU; 5-Ethynyl-2'-deoxyuridine; EdU |
| Research Areas | Cancer, Cell Signaling, DNA Damage and Repair, DNA/RNA, Epigenetics and Nuclear Signaling, Oxidation, Oxidative Stress, Post-translational Modifications |
| PubChem ID | 472172 |
| Scientific Background | 5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine that is used to monitor DNA synthesis through click chemistry (1). Unlike 5-bromo-2'-deoxyuridine (BrdU), EdU does not require sample fixation or DNA denaturation. It can then be detected using a fluorescent azide probe and copper catalysis using 1,3-dipolar cycloaddition. |
| References | 1. Salic A., and Mitchison, T.J. (2008) Proc. Natl. Acad. Sci. USA. 105:2415. |
Product Images
Chemical structure of 5-Ethynyl-2′-deoxyuridine (SIH-597), a DNA Labelling Agent. CAS #: 61135-33-9. Molecular Formula: C11H12N2O5. Molecular Weight: 252.2 g/mol.
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