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| Product Name | Lysophosphatidic Acid, Sodium Salt |
| Description |
Autophagy inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 22556-62-3 |
| Molecular Formula | C21H41O7P*Na |
| Molecular Weight | 458.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (1 mg/ml) and warm water (10 mg/ml). |
| Source | Synthetic |
| Appearance | White powder. |
| SMILES | C(O[P](=O)(O)O)C(O)COC(=O)CCCCCCCC=C/CCCCCCCC |
| InChI | InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-/t20-/m1/s1 |
| InChIKey | WRGQSWVCFNIUNZ-GDCKJWNLSA-N |
| Safety Phrases |
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Lysophosphatidic Acid, Sodium Salt (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-403) |
Biological Description
| Alternative Names | Oleoyl-lysophosphatidic acid sodium salt |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 5311263 |
| Scientific Background | Oleoyl-lysophosphatidic acid is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. It has been shown to induce cellular functions such as cell proliferation and migration, and ICAM-1, IL-8 and MCP-1 expression. Lysophosphatidic acid has also been observed to inhibit autophagy in cells under starvation conditions by inhibiting autophagosome formation. |
| References |
1. van Corven E.J., et al. (1992) Biochem J. 281(Pt 1): 163-9. 2. Chang C.L., et al. (2007) Autophagy. 3(3): 268-70. |
Product Images
Chemical structure of Lysophosphatidic Acid (SIH-403), a Autophagy inhibitor. CAS #: 22556-62-3 . Molecular Formula: C21H41O7P. Molecular Weight: 436.5245 g/mol.
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