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| Product Name | L-Ergothioneine |
| Description |
Neuronal protective |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 497-30-3 |
| Molecular Formula | C9H15N3O2S |
| Molecular Weight | 229.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Neuronal Protective |
| Solubility | May be dissolved in water (50 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white powder |
| SMILES | C[N+](C)(C)[C@@H](CC1=CNC(=S)N1)C(=O)[O-] |
| InChI | InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1 |
| InChIKey | SSISHJJTAXXQAX-ZETCQYMHSA-N |
| Safety Phrases |
Classification: Warning, Irritant GHS Hazard Statements, H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Precautionary Statement Codes,: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305 |
| Cite This Product | L-Ergothioneine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-634) |
Biological Description
| Alternative Names | (a-S)-a-Carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-1H-imidazole-4-ethanaminium inner salt; 2-Mercaptohistidine betaine; NSC-7175 |
| Research Areas | Apoptosis, Cancer, Cell Death, Neuroscience, Neuroregeneration |
| PubChem ID | 5351619 |
| Scientific Background | Naturally occurring ubiquitous antioxidant which is found in many cells at concentrations up to 2 mM (1). Rescues PC12 cells from -amyloid-induced apoptotic cell death (2). Protects against cisplatin-induced neuronal injury and enhances cognition in a mouse model (3). Interferes with endothelial cell senescence (4). |
| References |
1. IK Cheah and B Halliwell Biochim. Biophys. Acta 2012 1822:784 2. JH Jang et al. Free Radic. Biol. Med. 2004 36:288 3. TY Song et al. Food Chem. Toxicol. 2010 48:3492 4. N D’Onofrio et al. Free Radic. Biol. Med. 2016 96:211 |
Product Images
Chemical structure of L-Ergothioneine (SIH-634), a Neuronal protective. CAS #: 497-30-3. Molecular Formula: C9H15N3O2S. Molecular Weight: 229.3 g/mol.
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