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| Product Name | NSC 663284 |
| Description |
Cdc25 Phosphatase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 383907-43-5 |
| Molecular Formula | C15H16ClN3O3 |
| Molecular Weight | 321.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 50 mM in DMSO and to 50 mM in ethanol |
| Source | Synthetic |
| Appearance | Red solid |
| SMILES | C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl |
| InChI | InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2 |
| InChIKey | BMKPVDQDJQWBPD-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant |
| Cite This Product | NSC 663284 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-520) |
Biological Description
| Alternative Names | NSC-63284, 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione |
| Research Areas | Cell Signaling |
| PubChem ID | 379077 |
| Scientific Background | NSC 663284 is a potent and selective inhibitor of the CDC25 phosphatase family. Specifically, it has been shown to inhibit CDC25A, CDC25B and CDC25C. NSC 663284 is a cell-permeable and irreversible inhibitor. |
| References |
1. Lazo J.S., et al. (2001) J. Med. Chem. 44(24): 4042–4049. 2. Brisson M., et al. (2005) Mol. Pharm. 68(6): 1810–1820. |
Product Images
Chemical structure of NSC 663284 (SIH-520), a Cdc25 Phosphatase inhibitor. CAS #: 383907-43-5. Molecular Formula: C15H16ClN3O3. Molecular Weight: 321.8 g/mol.
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