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| Product Name | PD325901 |
| Description |
MEK kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 391210-10-9 |
| Molecular Formula | C16H14F3IN2O4 |
| Molecular Weight | 482.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 25 mM in DMSO |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O |
| InChI | InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 |
| InChIKey | SUDAHWBOROXANE-SECBINFHSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 3), H301 Specific target organ toxicity -repeated exposure (Category 2), H373 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H373 May cause damage to organs through prolonged or repeated exposure. H410 Very toxic to aquatic life with long lasting effects. Precautionary statements: P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P314 Get medical advice/ attention if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | PD325901 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-507) |
Biological Description
| Alternative Names | PD 0325901, PD-325901, N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 9826528 |
| Scientific Background | PD325901 is a potent MEK1 and MEK2 inhibitor. Specifically, it has been shown to suppress phosphorylation of ERK1/2 in murine colon 26 cells, as well as, its downstream target, ribosomal S6 kinase, in a dose-dependent manner. |
| References |
1. Barrett S.D., et al. (2008) Bioorganic. Med. Chem. Letters. 18(24): 6501–6504. 2. Ciuffreda L., et al. (2009) Neoplasia. 11(8): 720–731. |
Product Images
Chemical structure of PD325901 (SIH-507), a MEK kinase inhibitor. CAS #: 391210-10-9. Molecular Formula: C16H14F3IN2O4. Molecular Weight: 482.2 g/mol.
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