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| Product Name | Picropodophyllotoxin |
| Description |
IGF1R inhibitor |
| Purity | >96% (HPLC) |
| CAS No. | 477-47-4 |
| Molecular Formula | C22H22O8 |
| Molecular Weight | 414.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (10 mg/ml, warm) or dimethyl formamide (25 mg/ml) |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | [C@H]25[C@H]([C@@H](C1=CC3=C(C=C1[C@@H]2O)OCO3)C4=CC(=C(C(=C4)OC)OC)OC)C(OC5)=O |
| InChI | InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1 |
| InChIKey | YJGVMLPVUAXIQN-HAEOHBJNSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 3), H301 Acute toxicity, Dermal (Category 4), H312 Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H312 Harmful in contact with skin. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P322 Specific measures (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well - ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Picropodophyllotoxin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-467) |
Biological Description
| Alternative Names | Picropodophyllin, NSC 36407, PPP, (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one |
| Research Areas | Cell Signaling |
| PubChem ID | 72435 |
| Scientific Background | Picropodophyllotoxin is an inhibitor of insulin-like growth factor 1 receptor (IGF1R). Specifically, it inhibits IGF1R autophosphorylation. It has also been seen to increases the fraction of cells in the G2/M phase, reduce pAKT and pERK1/2, and upregulates apoptosis. Picropodophyllotoxin exhibits antiproliferative effects in multiple cancer cell lines. |
| References |
1. Girnita A., et al. (2004) Cancer Res. 64(1): 236–242. 2. Strömberg T., et al. (2006) Blood. 107(2): 669–678. |
Product Images
Chemical structure of Picropodophyllotoxin (SIH-467), a IGF1R inhibitor. CAS #: 477-47-4. Molecular Formula: C22H22O8. Molecular Weight: 414.4 g/mol.
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