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| Product Name | Piperlongumine |
| Description |
Apoptosis Inducer |
| Purity | >98% |
| CAS No. | 20069-09-4 |
| Molecular Formula | C17H19NO5 |
| Molecular Weight | 317.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble in 25 mg/ml DMSO |
| Source | Synthetic |
| Appearance | Cream Solid |
| SMILES | COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O |
| InChI | InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3 |
| InChIKey | VABYUUZNAVQNPG-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302 |
| Cite This Product | Piperlongumine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-156) |
Biological Description
| Alternative Names | 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone |
| Research Areas | Cancer, Oxidative Stress |
| PubChem ID | 637858 |
| Scientific Background | Piperlongumine is a novel compound that exhibits a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid and platelet activating factor, without any inhibiting effect on that induced by thrombin (1). It has recently been found to kill cancer cells by blocking the response that dissipates high oxidative stress and the resulting reactive oxygen species (ROS) generated, meanwhile sparing normal cells (2). |
| References |
1. Park B.S., et al. (2008) Phytother Res. 22(9): 1195-1199. 2. Raj L., et al. (2011) Nature. 475(7355): 231. |
Product Images
Chemical structure of Piperlongumine (SIH-156), a Apoptosis inducer in oxidative stressed cells. CAS #: 20069-09-4. Molecular Formula: C17H19NO5. Molecular Weight: 317.3 g/mol.
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