Product Name | PP2 |
Description |
Src kinase inhibitor |
Purity | >98% (TLC); NMR (Conforms) |
CAS No. | 172889-27-9 |
Molecular Formula | C15H16ClN5 |
Molecular Weight | 301.8 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Inhibitor |
Solubility | May be dissolved in DMSO (25mg/mL); or ethanol (3mg/mL, warm) |
Source | Synthetic |
Appearance | Off-white solid |
SMILES | C1=C(C=CC(=C1)Cl)C2=N[N](C3=C2C(=NC=N3)N)C(C)(C)C |
InChI | InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19) |
InChIKey | PBBRWFOVCUAONR-UHFFFAOYSA-N |
Safety Phrases |
Classification: Acute Toxicity: Oral, Category 3 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301: Toxic if swallowed. Precautionary statements: P264: Wash {hands} thoroughly after handling. P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P330: Rinse mouth |
Cite This Product | PP2 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-470) |
Alternative Names | 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
PubChem ID | 4878 |
Scientific Background | PP2 is a selective inhibitor of Src-family tyrosine kinases. PP2 has been shown to inhibit Lck, FynT, and phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). PP2 displays > 10000-fold selectivity over ZAP-70 and JAK2. |
References |
1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701. 2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678. |
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