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| Product Name | Puromycin HCl |
| Description |
Translation inhibitor |
| Purity | >98% (TLC, HPLC); NMR (Conforms) |
| CAS No. | 58-58-2 |
| Molecular Formula | C22H29N7O5•2HCl |
| Molecular Weight | 544.43 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (50 mg/ml); or water (50 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O |
| InChI | InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5 |
| InChIKey | RXWNCPJZOCPEPQ-WABMVTPESA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Puromycin HCl (StressMarq Biosciences, Canada, Cat # SIH-248) |
Biological Description
| Alternative Names | 3'-Deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5891 |
| Scientific Background | Puromycin is an antibiotic that is a protein synthesis inhibitor that causes premature chain termination during translation taking place in the ribosome. Part of the molecule resembles the 3' end of the tRNA. It enters the A site and transfers to the growing chain, causing the premature release. It is not selective for either prokaryotes or eukaryotes. |
| References | 1. Azzam and Algranati. (1973) Proc Natl Acad Sci. 70: 3866. |
Product Images
Chemical structure of Puromycin HCl (SIH-248), a Translation inhibitor. CAS #: 58-58-2. Molecular Formula: C22H29N7O5 x 2HCl. Molecular Weight: 544.43 g/mol.
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Based on validation through cited publications.