Rapamycin

Name: Rapamycin
SKU: SIH-212
Availability: InStock

mTOR inhibitor

Catalog No. SIH-212

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CAS No.	53123-88-9
Molecular Formula	C51H79NO13

SKU: SIH-212 Categories: Inhibitor, Small Molecules

Product Name	Rapamycin
Description	mTOR inhibitor
Purity	>98%
CAS No.	53123-88-9
Molecular Formula	C₅₁H₇₉NO₁₃
Molecular Weight	914.18
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 100 mM in ethanol, and to 50 mM in DMSO
Source	Synthetic
Appearance	White Solid
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
InChI	InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-
InChIKey	QFJCIRLUMZQUOT-HPLJOQBZSA-N
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effect
Cite This Product	Rapamycin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-212)

Alternative Names	(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-{1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2-propanyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatr icyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene2,3,10,14,20-pentone
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, mTOR Inhibitors
PubChem ID	5284616
Scientific Background	Rapamycin or Sirolimus is an immunosuppressant and antifungal. It inhibits the response to interleukin-2, and therefore blocks activation of T and B cells. It binds FKBP12 which then inhibits the mTOR pathway (1). There is also potential treatment for Alzheimer;s, autism and HIV infection (2-3).
References	1. Gruppuso P.A., Boylan J.M., and Sanders J.A. (2011) Cell Cycle. 10(7): EPub. 2. Ehninger D., et al. (2008) Nat. Med. 14(8): 843-848. 3. Donia M., McCubrey J.A., Bendtzen K., and Nicoletti F. (2010) Br J Clin Pharmacol. 70(6): 784-793.

Chemical structure of Rapamycin (SIH-212), a mTOR inhibitor. CAS #: 53123-88-9. Molecular Formula: C51H79NO13 . Molecular Weight: 914.18 g/mol.

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