Roscovitine

Name: Roscovitine
SKU: SIH-472
Availability: InStock

p34/cdc2 inhibitor

Catalog No. SIH-472

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CAS No.	186692-46-6
Molecular Formula	C19H26N6O

SKU: SIH-472 Categories: Inhibitor, Small Molecules

Product Name	Roscovitine
Description	p34/cdc2 inhibitor
Purity	>99% (TLC and HPLC); NMR (Conforms)
CAS No.	186692-46-6
Molecular Formula	C₁₉H₂₆N₆O
Molecular Weight	354.4
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	May be dissolved in ethanol (10mg/mL); or DMSO (10mg/mL, warm)
Source	Synthetic
Appearance	White to off-white solid
SMILES	[C@H](NC2=NC1=C(N=C[N]1C(C)C)C(=N2)NCC3=CC=CC=C3)(CO)CC
InChI	InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChIKey	BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product	Roscovitine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-472)

Alternative Names	2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine, 2(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
Research Areas	Cell Signaling
PubChem ID	160355
Scientific Background	Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). It is specifically selective for CDK1/cyclin B kinase, CDK2 and CDK5/p35. It inhibits M phase promoting factor kinase activity and affects calcium channel gating.
References	1. De Azevedo, et al. (1997) Eur. J. Biochem. 243(1-2): 518–526.

Chemical structure of Roscovitine (SIH-472), a p34/cdc2 inhibitor. CAS #: 186692-46-6. Molecular Formula: C19H26N6O. Molecular Weight: 354.4 g/mol.

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