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| Product Name | Src I1 |
| Description |
Src kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 179248-59-0 |
| Molecular Formula | C22H19N3O3 |
| Molecular Weight | 373.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (5 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OC4=CC=CC=C4)OC |
| InChI | InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25) |
| InChIKey | DMWVGXGXHPOEPT-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 4), H302 Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Chronic aquatic toxicity (Category 4), H413 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H413 May cause long lasting harmful effec ts to aquatic life. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/ eye protection/ face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supple mental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash be fore reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant |
| Cite This Product | Src I1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-478) |
Biological Description
| Alternative Names | 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine, SKI-1, Src Inhibitor-1 |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 1474853 |
| Scientific Background | SrcI1 is a potent and competitive dual site Src kinase inhibitor. It has been shown as a potent inhibitor of the Src and Lck kinase, as well as, VEGFR2 and c-fms. SrcI1 is cell permeable and can induce apoptosis. |
| References |
1. Bain, J., et al. (2007) Biochem. J. 408(3): 297–315. 2. Leung, E. L.H., et al. (2009) Mol. Cancer. Res: MCR. 7(6): 923–932. |
Product Images
Chemical structure of Src I1 (SIH-478), a Src kinase inhibitor. CAS #: 179248-59-0. Molecular Formula: C22H19N3O3. Molecular Weight: 373.4 g/mol.
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