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| Product Name | STF-62247 |
| Description |
Autophagy inducer |
| Purity | >98% |
| CAS No. | 315702-99-9 |
| Molecular Formula | C15H13N3S |
| Molecular Weight | 267.35 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble in DMSO (26 mg/ml). |
| Source | Synthetic |
| Appearance | Solid |
| SMILES | CC1=CC=CC(=C1)NC2=NC(=CS2)C3=CC=NC=C3 |
| InChI | InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18) |
| InChIKey | KATNUHQNJGNLPW-UHFFFAOYSA-N |
| Safety Phrases |
Classification: D1B- Toxic Material Causing Immediate and Serious, Toxic Effects, Toxic by ingestion, D2B- Toxic Material Causing Other Toxic Effects, Moderate eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H319- Causes serious eye irritation. Precautionary statements: P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Cite This Product | STF-62247 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-396) |
Biological Description
| Alternative Names | N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 704473 |
| Scientific Background | STF-62247 is a selective cell-permeable inducer of autophagy. This is demonstrated by an induction of large vacuole formation in cells. This observation is especially pronounced in von Hippel-Lindau deficient renal carcinoma cells. Induction of autophagy is also seen in vivo in mice. |
| References | 1. Turcotte S., et al. (2008) Autophagy, 4(7): b944-6. |
Product Images
Chemical structure of STF-62247 (SIH-396), a Autophagy inducer. CAS #: 315702-99-9. Molecular Formula: C15H13N3S . Molecular Weight: 267.35 g/mol.
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