Discovery through Partnership | Excellence through Quality
| Product Name | Terazosin Hydrochloride |
| Description |
Alpha adrenergic antagonist, and Hsp90 Activator |
| Purity | >98% |
| CAS No. | 63074-08-8 |
| Molecular Formula | C19H25N5O4·HCl |
| Molecular Weight | 423.89 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antagonist |
| Solubility | Soluble to 20mg/ml in warm water |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | C1=C(OC)C(=CC2=C1C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC.[Cl-].O |
| InChI | InChI=1S/C19H25N5O4.ClH.H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;/h10-11,1 |
| InChIKey | MWYNOTLRCUQCKD-UHFFFAOYSA-M |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard Statements: H302 - Harmful if swallowed. |
| Cite This Product | Terazosin Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-516) |
Biological Description
| Alternative Names | 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine |
| Research Areas | Alpha-2 Adrenergic Receptors, Apoptosis, Cancer, Neuroscience, Neurotransmitter Receptors |
| PubChem ID | 44383 |
| Scientific Background | Terazosin (TZ) which is marketed as an alpha1-adrenergic receptor antagonist, has been shown to alleviate organ damaged and increase survival in rodent models of sepsis and stroke in vivo (1). It inhibits apoptosis in macrophages by activation of Pgk1 and Hsp90 (1). |
| References |
1. Chen X., et al. (2015) Nature Chem Biol. 11:19-25. 2. Hancock A.A., et al. (1995) J Recept Signal Transduct Res. 15: 863. 3. Kyncl J.J. (1986) Am J Med. 80:12. |
Product Images
Chemical structure of Terazosin Hydrochloride (SIH-516), a Alpha adrenergic antagonist, and Hsp90 Activator. CAS #: 63074-08-8. Molecular Formula: C19H25N5O4 · HCl. Molecular Weight: 423.89 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.