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| Product Name | Tunicamycin |
| Description |
Autophagy inducer |
| Purity | >98% (HPLC) as a mixture of tunicamycin A, B, C and D |
| CAS No. | 11089-65-9 |
| Molecular Formula | C39H64N4O16 |
| Molecular Weight | 844.95 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble in DMSO (>10 mg/ml) or ethanol (5 mg/ml; warm). |
| Source | Isolated from Streptomyces lysosuperficus |
| Appearance | White solid. |
| SMILES | [C@@H]2(O[C@H](O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1NC(=O)C)CO)[C@H](NC(=O)C=CCC(C)C)[C@@H](O)[C@H]2O)CC(O)[C@H]4O[C@@H |
| Safety Phrases |
Classification: D1A- Very Toxic Material Causing Immediate and Serious Toxic Effects, Highly toxic by ingestion, D2A- Very Toxic Material Causing Other Toxic Effects, Teratogen- Reproductive hazard Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H300- Fatal if swallowed. Precautionary statements: P264- Wash hands thoroughly after handling. P301 + P310- IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. |
| Cite This Product | Tunicamycin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-397) |
Biological Description
| Alternative Names | Tunicamycin from Streptomyces sp. |
| Research Areas | Autophagy, Cancer |
| Scientific Background | As a nucleoside antibiotic, Tunicamycin blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. This causes an induction of glucose-regulated protein 78 (GRP78) mRNA expression, which in turn increases ER stress and subsequently induces autophagy. |
| References |
1. Unal E.S., et al. (2008) Biochim Biophys Acta. 1778(6): 1407-14. 2. Ding W.X., et al. (2007) J Biol Chem. 282(7): 4702-10. 3. Ishii S., et al. (1987) J Neurochem. 49(5): 1606-12. 4. Zhang J., et al. (2013) J Surg Res. 183(2): 929-35. |
Product Images
Chemical structure of Tunicamycin (SIH-397), a Autophagy inducer. CAS #: 11089-65-9. Molecular Formula: C39H64N4O16. Molecular Weight: 844.95 g/mol.
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