U-0126

Name: U-0126
SKU: SIH-380
Availability: InStock

MEK inhibitor

Catalog No. SIH-380

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CAS No.	109511-58-2
Molecular Formula	C18H16N6S2

SKU: SIH-380 Categories: Inhibitor, Small Molecules

Product Name	U-0126
Description	MEK inhibitor
Purity	>98%
CAS No.	109511-58-2
Molecular Formula	C₁₈H₁₆N₆S₂
Molecular Weight	380.5
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (>10 mg/ml), 100% ethanol (2 mg/ml)
Source	Synthetic
Appearance	White solid
SMILES	C2=C(SC(/N)=C(/C(=C(SC1=CC=CC=C1N)N)C#N)C#N)C(=CC=C2)N
InChI	InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChIKey	DVEXZJFMOKTQEZ-JYFOCSDGSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	U-0126 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-380)

Alternative Names	1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
Research Areas	Cell Signaling
PubChem ID	3006531
Scientific Background	U-0126 is a novel, potent and selective MEK inhibitor (MEK1; IC50=72nM, MEK2; IC50=58nM). Inhibits AP-1 transcription activity. Blocks the production of inflammatory cytokines and matrix metalloproteinases. Binding of extracellular growth factors to cell surface receptors often results in activation of the mitogen-activated protein kinase (MAPK). MAPK is regulated by MAPK kinase, also called MEK. Deprivation of growth factors during cell culture or intracellular MEK inhibition leads to inhibition of proliferation and apoptotic cell death. N Blank et al. (2002) have shown that U0126, a common used MEK inhibitor and compound that itself has no intrinsic fluorescence in vitro but develops an intensive fluorescence during cell culture which can be observed in all fluorescence channels with predominance in the FL1 channel (525nm).
References	1. Duncia J.V., et a.l (1998) Bioorg. Med. Chem. Lett. 8(20): 2839-44. 2. Favata M.F., et al. (1998) J. Biol. Chem. 273(29): 18623-32. 3. Davies S.P., et al. (2000) Biochem. J. 351(Pt1): 95-105. 4. Namura S., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(20): 11569-74.

Chemical structure of U-0126 (SIH-380), a MEK inhibitor. CAS #: 109511-58-2. Molecular Formula: C18H16N6S2. Molecular Weight: 380.5 g/mol.

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