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| Product Name | Urolithin A |
| Description |
Mitophagy inducer |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 1143-70-0 |
| Molecular Formula | C13H8O4 |
| Molecular Weight | 228.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | May be dissolved in DMSO (50 mg/ml) |
| Source | Synthetic |
| Appearance | Pale-yellow powder |
| SMILES | OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1 |
| InChI | InChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H |
| InChIKey | RIUPLDUFZCXCHM-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Irritant GHS07 Hazard Statements, H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Precautionary Statement Codes, P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 |
| Cite This Product | Urolithin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-610) |
Biological Description
| Alternative Names | 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; or 2',7-Dihydroxy-3,4-benzocoumarin |
| Research Areas | Alzheimer's Disease, Cancer, Neurodegeneration, Neuroscience, Parkinson's Disease |
| PubChem ID | 5488186 |
| Scientific Background | Urolithin A (UA) is a microbial metabolite of dietary ellagitannins produced in the gut (1). It has been shown to induce mitophagy and prolong lifespan in C. elegans and increase muscle function in rodents (2). It promotes mitophagy and suppresses NLRP3 inflammasome activation in LPS-induced BV2 microglial cells and in an MPTP-induced Parkinson’s disease model (3). The pro-mitophagy activity of Urolitin A may be beneficial in Alzheimer’s disease (4). Ex vivo UA-treated T cells display improved anti-tumor function (5). |
| References |
1.Gonzalez-Barrio R., et al. (2011) J. Agric. Food. Chem. 59:1152 2.Ryu D., et al. 2016 Nat. Med. 22:879 3.Qiu J., et al. 2022 Neuropharmacology 207:108963 4.Jayatunga D.P.W., et al. 2021 Nutrients. 13:3744 5.Denk D., et al. 2022 Immunity. 55:2059 |
Product Images
Chemical structure of Urolithin A (SIH-610), a Mitophagy inducer. CAS #: 1143-70-0. Molecular Formula: C13H8O4 . Molecular Weight: 228.2 g/mol.
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