Wortmannin

Name: Wortmannin
SKU: SIH-392
Availability: InStock

Autophagy inhibitor

Catalog No. SIH-392

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CAS No.	19545-26-7
Molecular Formula	C23H24O8

SKU: SIH-392 Categories: Inhibitor, Small Molecules

Product Name	Wortmannin
Description	Autophagy inhibitor
Purity	>98%
CAS No.	19545-26-7
Molecular Formula	C₂₃H₂₄O₈
Molecular Weight	428.44
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (50 mg/ml), methanol (5 mg/ml) or 100% ethanol (25 mg/ml).
Source	Synthetic
Appearance	White to off-white solid.
SMILES	[C@@]15(C4=C(C(C2=C1[C@@H](C[C@]3([C@H]2CCC3=O)C)OC(=O)C)=O)OC=C4C(O[C@@H]5COC)=O)C
InChI	InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
InChIKey	QDLHCMPXEPAAMD-QAIWCSMKSA-N
Safety Phrases	Classification: D1A- Very Toxic Material Causing Immediate and Serious Toxic Effects, Highly toxic by ingestion, Highly toxic by skin absorption Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H300 + H310- Fatal if swallowed or in contact with skin H330- Fatal if inhaled. Precautionary statements: P260- Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264- Wash hands thoroughly after handling. P280- Wear protective gloves/ protective clothing. P284- Wear respiratory protection. P302 + P350- IF ON SKIN: Gently wash with plenty of soap and water. P310- Immediately call a POISON CENTER or doctor/ physician.
Cite This Product	Wortmannin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-392)

Alternative Names	SL-2052, KY12420
Research Areas	Autophagy, Cancer
PubChem ID	312145
Scientific Background	Wortmannin is a steroid metabolite from the fungi Penicillium funiculosum. It specifically and irreversibly inhibits phosphatidylinositol 3-kinase (PI3-K). This in turn has been shown to inhibit the metabolic effects of insulin, yet the insulin receptor kinase activity is not altered. Because PI3-K is involved in membrane trafficking, and membrane trafficking is important in autophagy, Wortmannin also inhibits autophagy.
References	1. Powis G., et al. (1994). Cancer Res. 54(9): 2419-23. 2. Hazeki O., et al. (1996). J Lipid Mediat Cell Signal. 14(1-3): 259-61. 3. Lee A., et al. (1995). FEBS Lett. 361(1): 51-4. 4. Blommaart E. F., et al. (1997). Eur J Biochem. 243(1-2): 240-6.

Chemical structure of Wortmannin (SIH-392), a Autophagy inhibitor. CAS #: 19545-26-7. Molecular Formula: C23H24O8. Molecular Weight: 428.44 g/mol.

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