Multiple System Atrophy

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  • Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Monomers

    Human Recombinant Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Monomers

    Catalog No. SPR-503

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    Expression System E. coli
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    SPR-503_Alpha-Synuclein-TNG-A53T-S87N-N103G-Mutant-Monomers-Protein-SDS-Page-1.png
    Thioflavin T assay of Human Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Monomers Protein (SPR-503)

  • Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils

    Human Recombinant Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils

    Catalog No. SPR-504

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    Expression System E. coli
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    SPR-504_Alpha-Synuclein-TNG-A53T-S87N-N103G-Mutant-Pre-formed-Fibrils-Protein-TEM-1.png
    SDS-Page of Human Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils Protein (SPR-504)Thioflavin T assay of Human Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils Protein (SPR-504)Sedimentation assay of Human Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils Protein (SPR-504)TEM of Human Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils Protein (SPR-504)TEM of Human Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils Protein (SPR-504)

  • Anti-Bassoon Antibody

    Rabbit Anti-Human Bassoon Polyclonal

    Catalog No. SPC-198

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    Species Reactivity Hu, Ms, Rt
    Applications WB IHC ICC/IF FCM IP
    SKU: SPC-198 Categories: ,

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    SPC-198_Bassoon_Antibody_IHC_Mouse_Muscle_1.png
    Rabbit Anti-Bassoon Antibody used in Western blot (WB) on brain cell lysates (SPC-198)

  • Anti-LRRK2/Dardarin Antibody [N231B/34 (Formerly sold as S231B-34)]

    Mouse Anti-Human LRRK2/Dardarin Monoclonal IgG2a

    Catalog No. SMC-445

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    Species Reactivity Hu, Rt
    Applications WB IHC ICC/IF FCM IP
    SKU: SMC-445 Categories: ,

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    SMC-445_LRRK2-Dardarin_Antibody_N231B-34_ICC-IF_Human_Neuroblastoma-cells-SH-SY5Y-Composite-1.png
    Mouse Anti-LRRK2/Dardarin Antibody [N231B/34] used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Neuroblastoma cell line (SK-N-BE) (SMC-445)Mouse Anti-LRRK2/Dardarin Antibody [N231B/34] used in Western Blot (WB) on Rat Brain Membrane (SMC-445)

  • Anti-LRRK2/Dardarin Antibody [N138/6 (Formerly sold as S138-6)]

    Mouse Anti-Human LRRK2/Dardarin Monoclonal IgG1

    Catalog No. SMC-446

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    Species Reactivity Hu, Ms, Rt
    Applications WB IHC ICC/IF FCM IP
    SKU: SMC-446 Categories: ,

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    SMC-446_LRRK2-Dardarin_Antibody_N138-6_ICC-IF_Human_Neuroblastoma-cells-SH-SY5Y-Composite-1.png
    Mouse Anti-LRRK2/Dardarin Antibody [N138/6] used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Neuroblastoma cell line (SK-N-BE) (SMC-446)Mouse Anti-LRRK2/Dardarin Antibody [N138/6] used in Western Blot (WB) on Rat Brain Membrane (SMC-446)

  • Tau and Alpha Synuclein Co-Polymer Fibrils

    Human Recombinant Tau-352 (fetal 0N3R) and Human Recombinant Alpha Synuclein Co-Polymer Fibrils

    Catalog No. SPR-494

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    Expression System E. coli
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    SPR-494_Tau-and-Alpha-Synuclein-co-polymer-fibrils-Protein-TEM-1.png
    Immuno-TEM of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-494)SDS-Page of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-494)Thioflavin T assay of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-494)

  • Tau and Alpha Synuclein Co-Polymer Fibrils

    Human Recombinant Tau-441 (2N4R) and Human Recombinant Alpha Synuclein Co-Polymer Fibrils

    Catalog No. SPR-495

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    Expression System E. coli
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    SPR-495_Tau-and-Alpha-Synuclein-co-polymer-fibrils-Protein-TEM-1.png
    Immuno-TEM of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-495)SDS-Page of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-495)Thioflavin T assay of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-495)

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Protein Monomers (Type 2)

    Catalog No. SPR-316

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    Expression System E. coli
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    SPR-316_Alpha-Synuclein-Protein-Monomer-Protein-SDS-Page-1.png
    Alpha Synuclein monomers (SPR-316) do not form new alpha synuclein fibrils when combined with Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by a limited increase in fluorescence intensity by Thioflavin T over time.Alpha Synuclein Monomer RT-QuiC AssayΑlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.LDH assay shows effect of alpha synuclein monomers on mouse primary neuronsMTT assay shows effects of alpha synuclein monomers on mouse primary neurons

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2)

    Catalog No. SPR-317

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    Expression System E. coli
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    SPR-317_Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-4.png
    TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-317)Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.SDS-Page of Type 2 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-317)Type 2 alpha synuclein Pre-formed fibrils (SPR-317) do not seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) at the same rate as Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by lower fluorescence intensity values of Thioflavin T over time.Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)LDH assay shows effect of alpha synuclein PFFs on mouse primary neuronsMTT assay effects of alpha synuclein PFFs on mouse primary neurons

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Protein Monomers (Type 1)

    Catalog No. SPR-321

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    Expression System E. coli
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    SPR-321_Alpha-Synuclein-Protein-Monomer-Thioflavin-T-assay-1.png
    SDS-Page of huma alpha synuclein monomer (SPR-321)

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)

    Catalog No. SPR-322

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    Expression System E. coli
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    SPR-322_Alpha-Synuclein-Protein-Preformed-Fibrils-Protein-TEM-7.png
    Αlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.StressMarq’s Alpha Synuclein PFFs (red) cat#SPR-322, were shown to be taken up by SH-SY5Y cells and transmitted to neuronal iPSCs within 14 days.SDS-Page of Type 1 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-322)Type 1 alpha synuclein Pre-formed Fibrils (SPR-322) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) as shown by increased fluorescence intensity by Thioflavin T over time.Immunocytochemistry/Immunofluorescence of Human Alpha Synuclein Protein Protein (SPR-322)Mouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFsMouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFs cause endogenous alpha synuclein phosphorylationTEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-322)IHC of Sprague-Dawley rat brain injected with Type 1 human alpha synuclein Pre-formed Fibrils (SPR-322)Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)

  • CZC 54252 Hydrochloride

    LRRK2 inhibitor

    Catalog No. SIH-439

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    CAS No. 1191911-27-9, 1330003-04-7
    Molecular Formula C22H26Cl2N6O4S
    SKU: SIH-439 Categories: ,

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    SIH-439_CZC-54252_Hydrochloride_Chemical_Structure.png