Neurodegeneration

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  • MOLECULAR SIGNATURE® VPS35 Kit

    Colorimetric measurement of VPS35

    Catalog No. SKT-141

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    Species Reactivity Human, Mouse, Rat
    Sample Types Cell Lysate, Tissue
    SKU: SKT-141 Categories: ,

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    SKT-141_VPS35_Kit_Typical_Standard_Curve
    Graph of the Linearity Recovery for the VPS35 Kit - SKT-141Graph of the VPS35 Determination of WT-A549 vs KN-549 Lysates Graph for the VPS35 Kit MOLECULAR SIGNATURE® - SKT-141

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Protein Monomers (Type 2)

    Catalog No. SPR-316

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    Expression System E. coli
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    SPR-316_Alpha-Synuclein-Protein-Monomer-Protein-SDS-Page-1.png
    Alpha Synuclein monomers (SPR-316) do not form new alpha synuclein fibrils when combined with Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by a limited increase in fluorescence intensity by Thioflavin T over time.Alpha Synuclein Monomer RT-QuiC AssayΑlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.LDH assay shows effect of alpha synuclein monomers on mouse primary neuronsMTT assay shows effects of alpha synuclein monomers on mouse primary neurons

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2)

    Catalog No. SPR-317

    5.00 out of 5 based on 2 customer ratings
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    Expression System E. coli
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    SPR-317_Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-4.png
    TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-317)Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.SDS-Page of Type 2 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-317)Type 2 alpha synuclein Pre-formed fibrils (SPR-317) do not seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) at the same rate as Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by lower fluorescence intensity values of Thioflavin T over time.Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)LDH assay shows effect of alpha synuclein PFFs on mouse primary neuronsMTT assay effects of alpha synuclein PFFs on mouse primary neurons

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Protein Monomers (Type 1)

    Catalog No. SPR-321

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    Expression System E. coli
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    SPR-321_Alpha-Synuclein-Protein-Monomer-Thioflavin-T-assay-1.png
    SDS-Page of huma alpha synuclein monomer (SPR-321)

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)

    Catalog No. SPR-322

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    Expression System E. coli
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    SKU: SPR-322 Category:

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    SPR-322_Alpha-Synuclein-Protein-Preformed-Fibrils-Protein-TEM-7.png
    Αlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.StressMarq’s Alpha Synuclein PFFs (red) cat#SPR-322, were shown to be taken up by SH-SY5Y cells and transmitted to neuronal iPSCs within 14 days.SDS-Page of Type 1 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-322)Type 1 alpha synuclein Pre-formed Fibrils (SPR-322) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) as shown by increased fluorescence intensity by Thioflavin T over time.Immunocytochemistry/Immunofluorescence of Human Alpha Synuclein Protein Protein (SPR-322)Mouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFsMouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFs cause endogenous alpha synuclein phosphorylationTEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-322)IHC of Sprague-Dawley rat brain injected with Type 1 human alpha synuclein Pre-formed Fibrils (SPR-322)Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)

  • Bexarotene

    Retinoid RXR agonist

    Catalog No. SIH-535

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    CAS No. 153559-49-0
    Molecular Formula C24H28O2
    SKU: SIH-535 Categories: ,

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    SIH-535-Bexarotene-Chemical-Structure.png

  • CZC 54252 Hydrochloride

    LRRK2 inhibitor

    Catalog No. SIH-439

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    CAS No. 1191911-27-9, 1330003-04-7
    Molecular Formula C22H26Cl2N6O4S
    SKU: SIH-439 Categories: ,

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    SIH-439_CZC-54252_Hydrochloride_Chemical_Structure.png

  • Doxorubicin Hydrochloride

    Apoptosis inducer

    Catalog No. SIH-390

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    CAS No. 25316-40-9
    Molecular Formula C27H29NO11•HCl
    SKU: SIH-390 Categories: ,

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    SIH-390_Doxorubicin_Hydrochloride_Chemical_Structure.png

  • Fasudil

    ROCK inhibitor

    Catalog No. SIH-371

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    CAS No. 103745-39-7
    Molecular Formula C14H17N3O2S•HCl
    SKU: SIH-371 Categories: ,

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    SIH-371_Fasudil_Chemical_Structure.png

  • Galanthamine HBr

    Acetylcholinesterase inhibitor

    Catalog No. SIH-530

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    CAS No. 1953-04-4
    Molecular Formula C17H22BrNO3
    SKU: SIH-530 Categories: ,

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    SIH-530-Galanthamine-HBr-Chemical-Structure.png

  • Mn SOD Protein

    Rat Recombinant Mn SOD Protein

    Catalog No. SPR-130

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    Expression System E. coli
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    SPR-130_SOD-Mn_Protein_SDS-Page.png

  • Mn SOD Protein

    Human Recombinant Mn SOD Protein

    Catalog No. SPR-131

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    Expression System E. coli
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    SPR-131_SOD-Mn_Protein_SDS-Page.png

  • MOLECULAR SIGNATURE® Nitrotyrosine ELISA Kit

    Colorimetric detection of Nitrotyrosine

    Catalog No. SKT-126

    5.00 out of 5 based on 1 customer rating
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    Species Reactivity ALL
    Sample Types Cell lysates, Plasma, Serum, Urine
    SKU: SKT-126 Categories: ,

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    SKT-126_Nitrotyrosine_ELISA_Kit_Standard_Curve.png
    Diagram of the Competitive ELISA for the Nitrotyrosine ELISA Kit StressXpress - SKT-126Diagram of the Preparation of Nitrotyrosine Standards for the Nitrotyrosine ELISA Kit StressXpress - SKT-126Diagram of the Triplicate Sample Plate Format for the Nitrotyrosine ELISA Kit StressXpress - SKT-126

  • Pepstatin A

    Aspartic protease inhibitor

    Catalog No. SIH-533

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    CAS No. 26305-03-3
    Molecular Formula C34H63N5O9
    SKU: SIH-533 Categories: ,

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    SIH-533-Pepstatin-A-Chemical-Structure.png

  • Stattic

    STAT3 inhibitor

    Catalog No. SIH-554

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    CAS No. 19983-44-9
    Molecular Formula C8H5NO4S
    SKU: SIH-554 Categories: ,

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    SIH-554-Stattic-Chemical-Structure.png

  • Tolcapone

    COMT inhibitor

    Catalog No. SIH-540

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    CAS No. 134308-13-7
    Molecular Formula C14H11NO5
    SKU: SIH-540 Categories: ,

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    SIH-540-Tolcapone-Chemical-Structure.png