What is GABA?

GABA or γ-aminobutyric acid is a major inhibitory neurotransmitter in the mammalian central nervous system. GABA’s primary function is inhibiting or reducing the activity of the neurons to which it binds. Because of its role, GABA is considered a good supplement in reducing stress, anxiety and fear.

What is a GABA Receptor?

GABA receptors are membrane receptor proteins activated by GABA.

There are three classes of GABA receptors:

• GABA_A  –   Ionotropic Receptors                                            
• GABA_B –  Metabotropic Receptors
• GABA_C –   Ionotropic Receptors                                            

GABA_A receptors are the major fast inhibitory neurotransmitter gated chloride ion channels. When activated by GABA, they allow the flow of chloride ions (Cl^– ) across the cell membrane. GABA_A receptors are responsible for most of the physiological activities of GABA in the central nervous system.

GABA_B receptors are metabotropic transmembrane receptors that are linked via G proteins to potassium (K⁺) channels. When they bind to GABA, the coupled G proteins are activated and open the K⁺ channels, producing slow inhibitory postsynaptic potentials. GABA_B receptors are involved in a variety of psychiatric disorders and are considered potential drug targets.

GABA_C receptors, recently identified, are also linked to chloride channels like GABA_A. GABA_C receptors are found in many brain regions but they have been predominantly detected in the retina.

GABA Receptors research requires a great diversity of life science products. StressMarq is dedicated to developing cutting edge research products to aid in the study of GABA Receptors, including monoclonal antibodies, polyclonal antibodies, antibody conjugates, proteins, and small molecule inhibitors.

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